Full list of publications can be found on Pubmed and Google Scholar.
Selected Publications:
1. ALS/Frontotemporal Dementia (FTD) and Stem Cell Models of Disease
C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7
Wang KW*, Smeyers J*, Eggan K, Budnik B, Mordes DA. ACTA Neuropathologica Com., 2025.
Pluripotent stem cell strategies for rebuilding the human brain
Limone F, Klim JR, Mordes DA. Frontiers in Aging Neuroscience, 2022.
Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice
Mordes DA*, Morrison BM*, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang J, Eggan K, Rothstein JD. Neuron, 2020.
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage
2. Neuropathology of ALS and Neurodegenerative Diseases
Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS
Limone F*, Mordes DA*, Couto A, Joseph BJ, Mitchell JM, Therrien M, Ghosh SD, Meyer D, Zhang Y, Goldman M, Bortolin L, Cobos I, Stevens B, McCarroll SA, Kadiu I, Burberry A, Pietiläinen O, Eggan K. Nature Aging. 2024.
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP
Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. Nature Communications. 2024.
3. Movement Disorders and Alpha-synuclein Pathology
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication
Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy