Full list of publications can be found on Pubmed and Google Scholar.

Selected Publications:

1. ALS and Frontotemporal Dementia (FTD)

Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS

Limone F*, Mordes DA*, Couto A, Joseph BJ, Mitchell JM, Therrien M, Ghosh SD, Meyer D, Zhang Y, Goldman M, Bortolin L, Cobos I, Stevens B, McCarroll SA, Kadiu I, Burberry A, Pietiläinen O, Eggan K. Nature Aging. 2024 Jun 21. Epub ahead of print. PMID: 38907103.

Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice

Mordes DA*, Morrison BM*, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang J, Eggan K, Rothstein JD. Neuron, 2020.

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. ACTA Neuropathologica Comm., 2018.

Monitoring peripheral nerve degeneration in ALS cases and mouse models by label-free Stimulated Raman Scattering imaging

Tian F*, Yang W*, Mordes DA, Wang J, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu F, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K. Nature Communications, 2016.

Pluripotent stem cell strategies for rebuilding the human brain

Limone F, Klim JR, Mordes DA. Frontiers in Aging Neuroscience, 2022.

2. Movement Disorders and Alpha-synuclein Pathology

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. PNAS, 2015.

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication

Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB. PNAS, 2018.

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy

Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB. PLoS Pathogens, 2020.

3. Neuropathology and Clinical Correlations

Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock

Wheeler TM, Baker JN, Chad DA, Zilinski JL, Verzosa S, Mordes DA. New England Journal of Medicine, 2015.

Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia

Lin T, Ebb DH, Boepple PA, Thiele EA, Rincon SP, Mordes DA. New England Journal of Medicine, 2015.

4. DNA Damage Response Signaling

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

Hill, Mordes et al., PNAS.

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

Mordes DA, Glick GG, Zhao R, Cortez D. Genes and Development, 2008.

Activation of ATR and related PIKKs.

Mordes DA, Cortez D. Cell Cycle, 2008.

Dpb11 activates the Mec1-Ddc2 complex

Mordes DA, Nam EA, Cortez D. Proc. Natl. Acad. Sci. USA, 2008.