Publications

Mordes Lab on Pubmed and Google Scholar.

Selected Publications:

1. ALS/Frontotemporal Dementia (FTD) and Stem Cell Models of Disease

TBK1 Orchestrates Autophagy and Endo-lysosomal Pathways in Human Neurons

Mordes DA & Smeyers J. Autophagy 2026 Jan 4:1-3. 

Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks 

Smeyers J, Oses-Prieto JA, Yadanar L, Wang M, Iadarola M, Lu S, Wang KS, Watanabe TH, Debnath J, Burlingame AL, Mordes DA. Cell Reports, 2025.

C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7

Wang KW*, Smeyers J*, Eggan K, Budnik B, Mordes DA. Acta Neuropathologica Comm., 2025.

Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS

Limone F*, Mordes DA*, Couto A, Joseph BJ, Mitchell JM, Therrien M, Ghosh SD, Meyer D, Zhang Y, Goldman M, Bortolin L, Cobos I, Stevens B, McCarroll SA, Kadiu I, Burberry A, Pietiläinen O, Eggan K. Nature Aging. 2024.

Pluripotent stem cell strategies for rebuilding the human brain

Limone F, Klim JR, Mordes DA. Frontiers in Aging Neuroscience, 2022.

Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice

Mordes DA*, Morrison BM*, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang J, Eggan K, Rothstein JD. Neuron, 2020.

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

Hill, Mordes et al., PNAS.

2. Neuropathology of Alpha-synucleinopathies, CTE, and Additional Neurodegenerative Diseases

Molecular signatures of TDP-43-mediated cryptic exon dysregulation in chronic traumatic encephalopathy. Aytan N, Sullivan E, Nicks R, Wang KS, Hawkins S, Breen KA, Cherry JD, Alvarez VE, Watanabe T, Empawi J, Zhang X, Cormier KA, Labadorf A, Alosco ML, Mez J, McKee AC, Mordes DA*, Stein TD*; *co-senior. Brain (in press).

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs. Carroll EC, Yang H, Powell WC, Charvat AF, Oehler A, Jones JG, Montgomery KM, Yung A, Millbern Z, Taylor AIP, Wilkinson M, Ranson NA, Radford SE, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE. Nature Chemistry.  2025 Oct;17(10):1565-1575.

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.  

Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. Nature Communications. 2024.

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy

Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB. PLoS Pathogens, 2020.

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication

Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB. PNAS, 2018.

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. PNAS, 2015.