Abby Oehler

Staff Research Associate
Institute for Neurodegenerative Diseases
+1 415 502-7072

Why I work at the IND: Neurodegenerative diseases affect millions of people worldwide. I feel privileged to play even a minor role in helping those people.  

Publications: 

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.

Nature communications

Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE

Severe neurodegeneration in brains of transgenic rats producing human tau prions.

Acta neuropathologica

Ayers J, Lopez TP, Steele IT, Oehler A, Roman-Albarran R, Cleveland E, Chong A, Carlson GA, Condello C, Prusiner SB

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.

bioRxiv : the preprint server for biology

Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE

Kinetics of a-synuclein prions preceding neuropathological inclusions in multiple system atrophy.

PLoS pathogens

Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.

Acta neuropathologica

Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB

Structural heterogeneity and intersubject variability of Aß in familial and sporadic Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America

Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

Proceedings of the National Academy of Sciences of the United States of America

Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America

Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.

JAMA neurology

Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, Prusiner SB

A novel vector for transgenesis in the rat CNS.

Acta neuropathologica communications

Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB

Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.

Journal of virology

Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB

Towards authentic transgenic mouse models of heritable PrP prion diseases.

Acta neuropathologica

Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB

Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.

The Journal of pharmacology and experimental therapeutics

Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB

Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.

Journal of neuropathology and experimental neurology

Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond SJ

Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes.

Journal of neuropathology and experimental neurology

Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, DeArmond B, DeArmond SJ

Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Proceedings of the National Academy of Sciences of the United States of America

Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K

Propagation of prions causing synucleinopathies in cultured cells.

Proceedings of the National Academy of Sciences of the United States of America

Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB

Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.

The Journal of pharmacology and experimental therapeutics

Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB

White matter involvement in sporadic Creutzfeldt-Jakob disease.

Brain : a journal of neurology

Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG

Convection-enhanced delivery of AAV2-PrPshRNA in prion-infected mice.

PloS one

Ahn M, Bajsarowicz K, Oehler A, Lemus A, Bankiewicz K, DeArmond SJ

Evidence that bank vole PrP is a universal acceptor for prions.

PLoS pathogens

Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB

Transmission of multiple system atrophy prions to transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America

Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB

Drug resistance confounding prion therapeutics.

Proceedings of the National Academy of Sciences of the United States of America

Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K

Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.

The Journal of pharmacology and experimental therapeutics

Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB

Convergent replication of mouse synthetic prion strains.

The American journal of pathology

Ghaemmaghami S, Colby DW, Nguyen HO, Hayashi S, Oehler A, DeArmond SJ, Prusiner SB

Chimeric elk/mouse prion proteins in transgenic mice.

The Journal of general virology

Tamgüney G, Giles K, Oehler A, Johnson NL, DeArmond SJ, Prusiner SB

Purified and synthetic Alzheimer's amyloid beta (Aß) prions.

Proceedings of the National Academy of Sciences of the United States of America

Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K

Identification of I137M and other mutations that modulate incubation periods for two human prion strains.

Journal of virology

Giles K, De Nicola GF, Patel S, Glidden DV, Korth C, Oehler A, DeArmond SJ, Prusiner SB

Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein.

Proceedings of the National Academy of Sciences of the United States of America

Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB

Spontaneous generation of anchorless prions in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America

Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K

Protease-resistant prions selectively decrease Shadoo protein.

PLoS pathogens

Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB