Investigating the pathogenesis of neurodegenerative diseases and developing new therapeutic approaches

The Mordes Lab investigates the mechanisms of neurodegeneration in ALS (amyotrophic lateral sclerosis), frontotemporal dementia (FTD), and Parkinson's disease (PD) with the goal of creating paths forward for the development of new targeted therapies. We integrate studies of patient brain samples with human stem cell-derived neurons and mouse models using transcriptomic and proteomic approaches as well as traditional immunostaining techniques. We also collaborate with the Prusiner lab to investigate the role of pathological alpha-synuclein in movement disorders. Please check out this site to learn more about our team, publications, and current research projects.

Human stem cell-derived excitatory neurons

The Mordes Lab values the uniqueness of everyone. We strive to uphold a safe, creative space for scientific collaboration and pursuit.

We are welcoming enthusiastic graduate students and post-doctoral fellows to join our group (see open positions)!

NEWS

• May 2025: Dan gives talk at the Target ALS Annual Meeting in Boston. Thank you Amy, and Manish, and the entire team.
• Jan 2025: Julie and Dan present at the ALS Network Annual Research Summit, downtown. Thank you Clive and all the organizers.

Follow us on X: @MordesLab

Daniel Mordes, MD, PhD
1651 4th St., Mailroom 471A
San Francisco, CA, 94158, USA
(415) 353-1587