Welcome to the Mordes Lab

Investigating the pathogenesis of neurodegenerative diseases and developing new therapeutic approaches

The Mordes Lab aims to understand the mechanisms of neurodegeneration in ALS (amyotrophic lateral sclerosis) and related diseases and to establish better models of neurodegenerative diseases with the goal of creating paths forward for the development of targeted therapies. We study ALS and frontotemporal dementia (FTD) using human stem cell-derived neurons and mouse models. We examine patient brains and spinal cords using transcriptomic and proteomic approaches as well as traditional immunostaining techniques. We also collaborate with the Prusiner lab to investigate the role of pathological alpha-synuclein in movement disorders. Please check out this site to learn more about our team, publications, and current research projects.

Human stem cell-derived excitatory neurons.


We are looking for enthusiastic graduate students and post-doc fellows of diverse backgrounds and expertise (see open positions)!


  • Sept. 2022: Julie rocks the Weill Neurosciences seminar.
  • July 2022: Taylor joins our lab from the Tetrad program!
  • May 2022: Daniel presents recent ALS and FTD research at UCSF Memory and Aging Center Grand Rounds.
  • May 2022: New post-doctoral fellow officially joins our lab. Welcome Julie!
  • January 2022: New award received from the Frick Foundation for ALS Research for investigating the connection between familial ALS and loss of proteostasis.
  • November 2021: The lab receives funding from the Multiple System Atrophy Coalition to study the pathogenesis of MSA, a rare movement disorder.
  • November 2021: Daniel gives a research and career talk at the UCSF Pathology research interest group (RIG) meeting.

Follow us on Twitter: @MordesLab

The Mordes Lab is in the new Weill Neurosciences Building.

The Weill Neurosciences Building at Mission Bay, opened summer 2021! We are located on the 4th floor.















Daniel Mordes, MD, PhD
Weill Institute for Neurosciences 
1651 4th St., Mailroom 471A
San Francisco, CA, 94158, USA
(415) 353-1587