Welcome to the Mordes Lab

Investigating the pathogenesis of neurodegenerative diseases and developing new therapeutic approaches

The Mordes Lab investigates the mechanisms of neurodegeneration in ALS (amyotrophic lateral sclerosis), frontotemporal dementia (FTD), and Parkinson's disease (PD) with the goal of creating paths forward for the development of new targeted therapies. We integrate studies of patient brain samples with human stem cell-derived neurons and mouse models using transcriptomic and proteomic approaches as well as traditional immunostaining techniques. We also collaborate with the Prusiner lab to investigate the role of pathological alpha-synuclein in movement disorders. Please check out this site to learn more about our team, publications, and current research projects.

Human stem cell-derived excitatory neurons

The Mordes Lab values the uniqueness of everyone. We believe diversity and inclusivity are necessary for a healthy and thriving lab. We strive to uphold a safe, creative space for scientific collaboration and pursuit.

We are looking for enthusiastic graduate students and post-doc fellows of diverse backgrounds and expertise (see open positions)!

The Mordes Lab is based in the new UCSF Weill Neurosciences Building (background).


  • May 2024: Julie and Dan present at the annual Target ALS meeting.

Follow us on X: @MordesLab

Daniel Mordes, MD, PhD
1651 4th St., Mailroom 471A
San Francisco, CA, 94158, USA
(415) 353-1587